The reference site for Methylprednisolone

Methylprednisolone, sold under the brand names Depo-Medrol and Solu-Medrol among others, is a corticosteroid medication used to suppress the immune system and decrease inflammation.

WHAT IS Methylprednisolone?

Methylprednisolone relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis, skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis), severe allergies, and even asthma. Methylprednisolone is also used to treat certain types of cancer.

Methylprednisolone is a corticosteroid, which means that it is similar to a natural hormone produced by your adrenal glands. It is often used to replace this chemical when your body does not make enough of it.


Brand Name(s): Medrol
CAS nº: 2921-57-5
(meth ill pred niss’ oh lone)


Product Info

The sections below will provide you with more specific information and guidelines related to methylprednisolone and its correct use. Please read them carefully.

FDA Information

Methylprednisolone was originally approved by the FDA in 1957.

NOTE: methylprednisolone is FDA approved for the palliative treatment of leukemia or non-Hodgkin’s lymphoma in adults, and acute leukemia for childhood. It is also indicated for the treatment of hypercalcemia (high levels of calcium in the blood) associated with cancer.

Why is this medication prescribed?

Methylprednisolone is used to achieve prompt suppression of inflammation.

Examples of inflammatory conditions for which methylprednisolone is used include rheumatoid arthritis, systemic lupus erythematosus, acute gouty arthritis, psoriatic arthritis, ulcerative colitis, and Crohn’s disease.

Severe allergic conditions that fail conventional treatment also may respond to methylprednisolone. Examples of these include bronchial asthma, allergic rhinitis, drug-induced dermatitis, and contact and atopic dermatitis.

Chronic skin conditions treated with methylprednisolone include dermatitis herpetiformis, pemphigus, severe psoriasis and severe seborrheic dermatitis.

Chronic allergic and inflammatory conditions of the uvea, iris, conjunctiva and optic nerves of the eyes are also treated with methylprednisolone.

Other uses for this medicine

Methylprednisolone is sometimes used in combination with other drugs for the treatment of trauma to the spinal cord and brain.

Methylprednisolone is used in cats for the treatment of feline bronchial asthma, feline rodent ulcer (eosinophilic granuloma), feline inflammatory bowel disease, flea allergy dermatitis and miliary dermatitis.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Methylprednisolone comes in tablet form to be taken orally and also as an injection.

Always take methylprednisolone exactly as directed by your doctor. Do not take more or less than what has been prescribed to you. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each oral dose with a full glass of water. It can also be taken with food or milk to lessen stomach upsets.

As an injection, your healthcare provider will administer injectable methylprednisolone. If you are using injectable methylprednisolone at home, your healthcare provider will give you detailed instructions regarding preparation, administration, and storage of the medication.

If you are taking one dose daily, take that dose before 9 a.m. if possible, to follow the body’s natural cycle. If you take more than one dose daily, space the doses evenly throughout the day as directed by your doctor.

Do not stop taking methylprednisolone suddenly if you have been taking it for a few weeks. You may need a gradual reduction in dosage before you stop taking this medication completely.

Carry some type of medical identification that will let others know you are taking methylprednisolone in the case of an accident.

What special precautions should I follow?


Tell your doctor if you have any of the following: kidney disease, liver disease, high blood pressure or heart disease, ulcerative colitis, diverticulitis, stomach ulcers, hypothyroidism, a psychiatric condition, osteoporosis, myasthenia gravis, diabetes mellitus, or any other medical conditions.

Do not take methylprednisolone if you have a serious bacterial, viral, or fungal infection. Methylprednisolone weakens the body’s immune response and thus its ability to fight infection.

You may not be able to take methylprednisolone, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

Methylprednisolone is in the FDA pregnancy category C. This means that it is not known whether methylprednisolone will be harmful to an unborn baby. Do not take this medication without first talking with your doctor if you are pregnant or could become pregnant during treatment.

Methylprednisolone passes into breast milk and may affect a nursing baby. Do not take methylprednisolone without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Never take a double dose to make up for a missed one.

What side effects can this medication cause?

Side effects from using methylprednisolone may include:

increased appetite
difficulty sleeping (insomnia)
swelling in your ankles and feet (fluid retention)
sausea, take with food
muscle weakness
impaired wound healing
increased blood sugar levels. (Persons with diabetes may need to have blood sugar levels monitored more closely, including possible adjustments to diabetes medications).

Tell your doctor if any of these symptoms are severe or do not go away:

upset stomach
stomach irritation
increased hair growth
easy bruising
irregular or absent menstrual periods

If you experience any of the following symptoms, call your doctor immediately:

skin rash
swollen face, lower legs, or ankles
vision problems
cold or infection that lasts a long time
muscle weakness
black or tarry stool

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Always throw away any medication that is outdated or no longer needed and, if necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose whilst using this medication, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

obesity (especially around the stomach)
a round face
increased hair growth (especially around the face)
increased blood pressure
swollen hands, feet, or ankles (fluid retention)
sore or weak muscles

Product Images

PICTURES OF methylprednisolone PILLS

Below you will find images and specific information on the principal types of methylprednisolone that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 2 MG
Imprint: MEDROL 2
Manufacturer: PHARMACIA/UPJHN.

Strength(s): 4 MG
Imprint: GG 957
Manufacturer: SANDOZ

Strength(s): 4 MG
Imprint: TL001
Manufacturer: BRECKENRIDGE

Strength(s): 4 MG
Imprint: INV 351
Manufacturer: SANDOZ

Strength(s): 4 MG
Imprint: 4 | 3327 G
Manufacturer: GREENSTONE LTD.

Strength(s): 4 MG
Imprint: MEDROL 4
Manufacturer: PHARMACIA/UPJHN.

Strength(s): 8 MG
Imprint: MEDROL 8
Manufacturer: PHARMACIA/UPJHN.

Strength(s): 32 MG
Imprint: MEDROL 32
Manufacturer: PHARMACIA/UPJHN.

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